A recent study reveals that individuals who stop using blockbuster weight-loss injections like Mounjaro or Wegovy can put back on lost weight far faster than those who end conventional diet and exercise regimens.
Research printed in a major health publication demonstrates that while obese people can lose about a fifth of their body weight while on the medication, the weight returns at an average rate of nearly a kilo each month upon discontinuation.
"Users using such drugs should be aware of the danger of fast rebound weight gain when the therapy is stopped," warns lead investigator Dr. Susan Jebb.
That rate of regain suggests a reversion to original weight within about 18 months.
Comparing Approaches
The analysis, which examined 37 of studies involving thousands of participants, contrasted the effects of these new drugs with older methods.
The team emphasize that people who shed pounds through diet and exercise generally experience a more gradual weight regain—approximately 100 grams monthly—once they finish.
Explaining the Quick Rebound
Doctors suggest the mechanism of the jabs accounts for the amplified rebound.
GLP-1 drugs imitate a body's own chemical called GLP-1, which controls hunger.
"Long-term administration of GLP-1 levels far above than normal may cause the system to generate a reduced amount of its own natural hormone, and could diminish sensitivity to its effects," explained Dr. Adam Collins, a nutrition expert.
"Withdrawal of this hormone supplement results in hunger is unsuppressed, making overeating far more likely."
An Ongoing Condition?
Health authorities advise the jabs for individuals with weight-linked health risks, accompanied by prescribed diet and exercise modifications.
A number of clinicians contend that, due to the significant potential of weight regain, the therapy might need to be ongoing.
This opinion is supported by pharmaceutical companies, who note that the findings "underscore the chronic nature of excess weight," akin to managing diseases like hypertension.
User Accounts
Individuals who have discontinued the jabs describe a intense return of cravings.
"I experienced something activating and I was suddenly extremely hungry," described one woman.
The struggle is exacerbated if individuals have not established lasting dietary or behavioural modifications during therapy.
Significant Interest
Survey data suggest that millions of adults in the UK have used weight-loss jabs in the last 12 months, with interest being substantial.
- Use is higher among females compared to males.
- The middle-aged age group shows the greatest usage rates.
- Many access the medications through private prescriptions rather than the NHS.
Ultimately, clinicians stress that while GLP-1 drugs are effective agents for shedding pounds, they are not a magic solution and lasting health benefits likely depends on integrated lifestyle changes.
